2 posts tagged with "UK Biobank"

Biobank metabolomic and proteomic data can predict some long-term disease outcomes, but it is less clear whether historic molecular measurements help predict acute events around surgery. In a new medRxiv preprint, Richard Armstrong and colleagues test whether adding metabolomic and proteomic data improves prediction of postoperative complications after major surgery in UK Biobank.

Figure: Model performance across postoperative outcomes and feature sets, comparing clinical baseline models with metabolomic, proteomic and multiomic additions. Source: Armstrong et al., medRxiv, 2026, Fig. 2 (CC BY-NC-ND 4.0).

Serious complications after major surgery are common, but it is not always clear how far they reflect the immediate stress of surgery versus a person's underlying susceptibility to the same condition outside the postoperative period. In a medRxiv preprint, Richard Armstrong and colleagues use UK Biobank genetics to examine this question for five common postoperative complications.

Figure: Association between postoperative complications and increasing polygenic risk score quintile for related non-postoperative phenotypes. Source: Armstrong et al., medRxiv, 2025, Fig. 4 (CC BY-NC-ND 4.0).